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KMID : 0361119940080010095
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Korean Journal of Transplantation
1994 Volume.8 No. 1 p.95 ~ p.106
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The Role of Humoral Immune Response following Xenogenic Transplantation
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Abstract
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Organ transplantation today has become a widely accepted treatment modality for end-stage organ disease. The shortage of allogenic donors for organ transplantation has focused on xenotrasplantation as a source of a final solution for organ donation.
However, organ transplantations between different species have never been successful be-cause of hyperacute rejection. Although the mechanism of this phenomenon is not fully under-stood, many researchers believe that the natural antibodies present in the recipient´s serum may bind to the graft and induce the activation of complement cascade triggering the process of hyperacute rejection.
We performed the heart transplantation from a guinea pig to a rat in order to determine the role of immunoglobulin upon the xenotransplantation. The result were as follows.
1) After the xenogeneic and allogeneic heart transplantation, the mean graft survival in the rat was 31.5 minutes and 8.6 days respectively.
2) Mononuclear cell infiltration and other histologic changes in endocardium, myocardium and epicardium, were observed from the postoperative day 3 and showed peak level on postoperative day 5 in allograft. Cellular infiltrations were maintained until postoperative day 15 with the progression of myocardial necrosis.
In xenograft, perivascular edema was the only histologic finding from 5 minutes up to the postoperative 70 minutes.
3) IgG and IgM were expressed in allograft at early postoperative period regardless of allograft viability.
In xenograft IgG appeared in graft at an earlier stage than IgM and it appeared through all the layers of the transplantation heart while IgM was not present in the layer of myocardium.
Therefore humoral immune response is thought to act even in allograft as well as in xenograft.
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